Composition:  

Hydroxocobalamin 1000 ug/ml

Properties: 

• Depovit B₁₂ is a vitamin B₁₂ preparation with prolonged action.
• Vitamin B₁₂ is essential for growth, cell reproduction, hematopoiesis, nucleoprotein and myelin synthesis.
• Vitamin B₁₂ deficiency brings about the fatal disease of megaloblastic anaemia and/or neurological symptoms.
• Depovit B₁₂ (Hydroxocobalamin) with prolonged action is the only practicable method of restoring body needs of vitamin B₁₂.
• Depovit B₁₂ has the advantage of being painless and causes no local reactions.

  Indications:

• Pernicious anaemia, both uncomplicated and accompanied by nervous system involvement.
• Macrocytic anaemia or neuropathies caused by inadequate supply or absorption of vitamin B₁₂ such as
  • after resection of the stomach for gastric and duodenal ulcers, after ileocaecal resection and proctectomy with ileostomy.
  • inadequate nutrition, whether caused by under-nourishment or inappropriate diet, applying especially to elderly people and vegetarians whose diet is wholly without animal protein.
  • in tropical sprue, vitamin B₁₂ deficiency and subsequent megaloblastic anaemia are common; even in patients treated for years with conventional doses of folic acid, the serum levels of vitamin B₁₂ are found to be low. It has been reported that vitamin B₁₂ is as therapeutically effective as folic acid in the treatment and management of patients with tropical sprue.
  • in some cases, pregnancy may cause a drop in vitamin B₁₂ serum concentrations.
• Total gastrectomy
• Neurologists and neurosurgeons use aqueous solutions of vitamin B₁₂ to a great extent in neurological disorders of various etiologies, especially in painful conditions such as neuritis, radiculitis, trigeminal neuralgia, and in herpes zoster.
• Vitamin B₁₂ has also proved efficacious in male and female infertility caused by hypovitaminosis B12.

  Contraindications:

  Not to be used for newborn babies.

  Dosage and administration:

  Depovit B₁₂ ampoules should be given intramuscularly.

  • Usuat dose: Initially : 1 ampoule 1 -2 times weekly.
    • Maintenance treatment: 1 ampoule 1 -2 times monthly.
    • Severe cases : 1 ampoule 2-3 times weekly.
  • For anaemia: 1 ampoule every 4-6 weeks.
  • For Hypovitaminosis: 1 ampoule every week for 10 weeks.